자몽씨, 결명자 및 당귀에 의한 Streptococcus mutans의 증식 억제효과
Effect of Grapefruit seed, Cassiae torae Semen and Angelicae gigantis Radix on growth Streptococcus mutans
유윤정, 곽월아, 조장기, 장희순, 권호근, 이승일, 박용석,
소속 상세정보
유윤정 ( ) - 연세대학교 치과대학 구강생물학교실
곽월아 ( Kwak Wall-Ah ) - 연세대학교 치과대학 구강생물학교실
조장기 ( ) - 연세대학교 치과대학 구강생물학교실
장희순 ( ) - 연세대학교 치과대학 구강생물학교실
권호근 ( ) - 연세대학교 치과대학 구강생물학교실
이승일 ( ) - 연세대학교 치과대학 구강생물학교실
박용석 ( ) - 해태제과 식품연구소
KMID : 0355419960200010107
Abstract
Streptococcus mutans is an etiologic agent of dental caries and has been known to induce dental caries by the process of initial attachment, proliferation and acid production. For the prevention of dental caries which is caused by this process, extracts of natural products have recently been introduced. Therefore we isolated extracts from twenty two natural products and investigated the inhibitory effect of these extracts on growth of S. mutans using agar diffusion method. To investigate the possibility of using extracts from Grapefruit seed, Cassiae torae Semen and Angelicae gigantis Radix which presented growth inhibitory effect against S mutans as anticariologic agents, we made four mixtures of extracts from Grapefruit seed, Cassiae torae Semen and Angelicae gigantis Radix to reduce a bitter taste of Grapefruit seed. After we selected a mixture which had high growth inhibitory activity against S. mutans by agar diffusion method, we examined the effect of the selected mixture on the growth of S mutans according to exposure time. Extracts from Grapefruit seed inhibited the growth of S. mutans at 0.1 %, extracts from Cassiae torae Semen and Angelicae gigantis Radix also inhibited growth of S. mutans at I respectively. A mixture of extracts from Grapefruit seed, Cassiae
torae Semen and Angelicae gigantis Radix which was combined at 3: 3: 4 and 4: 2: 4 ratio presented wide growth inhibitory zone of S mutans. A mixture of extracts from Grapefruit seed, Cassiae torae Semen and Angelicae gigantis Radix which combined at 3: 3: 4 inhibited growth of S mutans - after 2 hour exposure at 0.1 % concentration. In conclusion, a mixture of extracts from Grapefruit seed, Cassiae torae Semen and Angelicae gigantis Radix turned out to be an effective anticariologic agent because this mixture inhibited growth of S. mutans which is the etiologic agent of dental caries during short exposure time at low concentration.
키워드
자몽씨;결명자;당귀;Streptococcus mutans;증식억제효과
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